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The treatment was generally well tolerated, although side effects were more frequent during the dose-escalating phase

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They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

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Nat Rev Mater 2022;7:31431

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Hereditary Retinal Degeneration in Rats Epithalon was studied in Campbell rats with inherited pigmentary retinal degeneration

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