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Although there was initial concern about pancreatitis (inflammation of the pancreas), large reviews have not shown a clear increased risk across the GLP-1 class

The PROactive 294 trial showed that pioglitazone, compared with a placebo, reduced the risk of composite outcomes (all-cause mortality, nonfatal MI and stroke) by 16% in diabetic patients with established ASCVD

Singh and Ecker, 2018