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Not only does glutathione protect the immune system by reducing levels of oxidative stress and inflammation, but it also helps to fortify the immune system in two key ways 8, 9 : Plays a critical role in supporting T lymphocyte (white blood cell) function Activated T cells produce free radicals, which trigger the glutathione (GSH) response required to buffer the increasing levels of ROS and prevent cellular damage Stimulates production and activity of natural killer (NK) cells NK cells play a critical role in the innate immune defense system and are reliant upon adequate levels of GSH

In fact, dysfunction in mitochondria and mitochondrial factors, also known as the mitochondrial dysfunction-associated senescence (MiDAS) 5 , can induce senescence and maybe a potential factor contributing to senescence in T1D and T2D pancreatic -cells

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Consequently, lower citrate ( m + 2)/PA ( m + 16) and malate ( m + 2)/PA ( m + 16) ratios were detected in shGDH1 cells (Supplementary Fig

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