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The endocrinology of perimenopause: need for a paradigm shift
In research, GH secretagogues are usually grouped into two major categories: GHRH analogs, which activate the growth hormonereleasing hormone receptor Ghrelin/GHSR agonists, which activate the growth hormone secretagogue receptor Both pathways can increase GH-axis activity, but they do so through different upstream signals
These peptides are thought to work by improving hormone production, which often declines during menopause
Patients should seek immediate medical attention by calling 999 or attending the nearest Accident & Emergency department if they experience: Chest pain or pressure , particularly if radiating to the arm, jaw, or back Severe shortness of breath or difficulty breathing at rest Dizziness, light-headedness, or fainting (syncope) Irregular heartbeat with symptoms such as chest pain or severe dizziness Non-urgent but important symptoms that warrant contact with your GP or NHS 111 within 2448 hours include: Persistent palpitations occurring daily or interfering with activities Sustained rapid heart rate at rest New-onset heart racing associated with anxiety or panic symptoms Palpitations accompanied by persistent nausea, vomiting, or inability to maintain hydration Any cardiovascular symptoms in patients with pre-existing heart disease Your healthcare provider may arrange investigations such as an electrocardiogram (ECG) , blood tests to assess electrolytes and thyroid function, or 24-hour Holter monitoring to characterise any rhythm disturbance
