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This suggests that Ex-4 mediates its protective effects through a GLP-1-R-SIRT1-p53 signaling axis [41]

If one medication leads to more significant weight loss and improved metabolic health, the long-term benefits may outweigh the short-term cost difference

A study has demonstrated that GPX4 inhibition can simultaneously activate the caspase-8-mediated apoptotic pathway and ferroptosis, suggesting shared upstream signaling mechanisms (143)

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Subsequent research has expanded the investigation to multiple tissue types and biological systems, with active areas including dermatological research, hair follicle biology, wound healing, and broader cellular regeneration studies