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Id also have to do a careful analysis and look for confounders - and there are many potentials

Previous research found that the salivary cortisol levels detected in a maximal progressive test using a cycle ergometer were significantly higher under the hot conditions (40 C) than under normal conditions (22 C) in nine young healthy men 23

Dropout rates of 15% were found in several long-term trials (12 months), with higher attrition in GLP-1 RA groups, potentially due to gastrointestinal side effects