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In addition to GSH inhibition, LCS3 is reported to inhibit the activity of thioredoxin reductase1 (TXNRD1), a critical antioxidant regulator maintaining the redox state of thioredoxin (TRX) [19](Supplementary Fig

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Overall, 0.5% of melanoma cases carried a potentially pathogenic variant in the POT1 gene.[127] A study of 290 familial melanoma cases (defined as families with at least two melanomas) from the United States, Italy, and Spain identified 16 POT1 carriers in 10 families

The study also noted a reduction in liver fat

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