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Conditions that disrupt intestinal neuromuscular signaling can cause secondary constipation (eg, multiple sclerosis, Parkinsons disease, spinal cord injury, diabetic neuropathy, and stroke) (Basilisco 2013

District Court judge denied a motion for a preliminary injunction that would have allowed certain compounding pharmacies to continue producing compounded versions of tirzepatide

AB-1002, a chimeric cardiotropic adeno-associated viral vector that delivers constitutively active protein phosphatase 1 inhibitor 1 to cardiomyocytes, improves cardiac function in preclinical models of heart failure

If diarrhea is explosive or forceful, it can cause small tears in the anal lining, leading to more discomfort