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doi:10.1007/s40265-021-01631-w Carruthers JD, Fagien S, Joseph JH, et al

Thus, organic acids in urine are often present at 100 times their concentration in the blood serum and thus are more readily detected in urine

The mechanisms behind this upregulation appear to involve: Activation of the Nrf2 pathway, which controls the expression of various antioxidant enzymes including GR Modulation of cellular signaling cascades that respond to redox status Alteration of mitochondrial metabolism, influencing NADPH availability for GR activity Reduction of inflammatory signaling that can suppress antioxidant enzyme expression These effects suggest that hydrogen water may provide a "hormetic" stimulusa mild oxidative challenge that triggers beneficial adaptive responses in cellular antioxidant systems

Early intervention is critical because cognitive impairment can lead to more severe conditions, such as Alzheimers or other forms of dementia

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