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Within the mitochondria, adenosylcobalamin serves as an absolute, non-negotiable requirement for the function of an enzyme called methylmalonyl-CoA mutase (MUT)

It has even been reported that some patients develop acquired resistance to therapy [227]

doi:10.1007/s12010-011-9436-3 Chen J, Xie L, Cai J, Yang C, Duan X (2013) Enzymatic synthesis of glutathione using engineered Saccharomyces cerevisiae

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